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64183-27-3

2'-Fluoro-2'-deoxyadenosine

Catalog#: AR0037RM  |   CAS#: 64183-27-3  |   MDL#: MFCD09750859  |   MF: C10H12FN5O3  |   MW: 269.2324

Packsize Purity Price Availability Quantity
100mg 95% $7.00 Global Stock Buy Now Add To Cart
250mg 95% $16.00 Global Stock Buy Now Add To Cart
1g 95% $40.00 Global Stock Buy Now Add To Cart
5g 95% $160.00 Global Stock Buy Now Add To Cart
10g 95% $288.00 Global Stock Buy Now Add To Cart
25g 95% $572.00 Global Stock Buy Now Add To Cart
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Catalog Number AR0037RM
Chemical Name 2'-Fluoro-2'-deoxyadenosine
CAS Number 64183-27-3
Molecular Formula C10H12FN5O3
Molecular Weight 269.2324
MDL Number MFCD09750859
SMILES OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1cnc2c1ncnc2N

2'-Fluoro-2'-deoxyadenosine, commonly referred to as 2'F-A, is a key compound utilized in chemical synthesis for its unique properties and versatile applications. This modified nucleoside has found significant use in the development of nucleotide analogs and pharmaceuticals due to its ability to mimic natural adenosine while offering improved stability and bioactivity.In chemical synthesis, 2'F-A serves as a valuable building block for the creation of nucleoside analogs with enhanced properties. Its incorporation into oligonucleotides and nucleic acids can confer resistance to nuclease degradation and increase binding affinity with complementary sequences. This makes it an invaluable tool in the design of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.Furthermore, the unique fluorine substitution at the 2' position of the ribose sugar in 2'F-A imparts distinct physicochemical properties that can be leveraged for specific applications. The fluorine atom not only confers increased hydrophobicity and lipophilicity but also influences the conformational preferences of the nucleoside, potentially leading to altered interactions with target molecules.Overall, the strategic incorporation of 2'-Fluoro-2'-deoxyadenosine in chemical synthesis enables researchers to fine-tune the properties of nucleotide analogs and pharmaceutical compounds, opening doors to a wide range of innovative applications in drug discovery, molecular biology, and biotechnology.
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