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49863-47-0

G418

Catalog#: AR00DF0M  |   CAS#: 49863-47-0  |   MDL#: MFCD30541267  |   MF: C20H40N4O10  |   MW: 496.5524

Packsize Purity Price Availability Quantity
10mg 97% $80.00 Global Stock Buy Now Add To Cart
25mg 97% $159.00 Global Stock Buy Now Add To Cart
50mg 97% $270.00 Global Stock Buy Now Add To Cart
100mg 97% $459.00 Global Stock Buy Now Add To Cart
250mg 97% $780.00 Global Stock Buy Now Add To Cart
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Catalog Number AR00DF0M
Chemical Name G418
CAS Number 49863-47-0
Molecular Formula C20H40N4O10
Molecular Weight 496.5524
MDL Number MFCD30541267
SMILES CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]1[C@H](N)C[C@@H]([C@H]([C@@H]1O)O[C@H]1O[C@H]([C@H](O)C)[C@H]([C@@H]([C@H]1N)O)O)N

Geneticin, also known as G418, is a potent antibiotic that is commonly used in genetic engineering and molecular biology research. This compound is derived from the bacterium Micromonospora rhodorangea and works by inhibiting protein synthesis in both prokaryotic and eukaryotic cells. In chemical synthesis, Geneticin is often utilized as a selective agent in cell culture systems to eliminate cells that have not been successfully transfected with a desired gene or plasmid.Geneticin functions by targeting the ribosomes in cells and interfering with the translation process, ultimately leading to cell death. This selective toxicity allows researchers to maintain only the cells that have successfully integrated and expressed the gene of interest. By controlling which cells survive in a culture, Geneticin enables the isolation and characterization of genetically modified cells, making it an invaluable tool in the field of genetic engineering.Additionally, Geneticin has found applications beyond cell culture, such as in the selection of antibiotic-resistant bacterial strains and the production of transgenic organisms. Its broad utility and efficacy in selectively eliminating non-transfected cells make it a crucial component in genetic manipulation techniques and a cornerstone in modern molecular biology research.
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