D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-3-fluoro-

Boc-D-Phe(3-F)-OH, also known as tert-butoxycarbonyl-D-phenylalanine(3-fluoro)-ol, is a crucial amino acid derivative widely utilized in chemical synthesis. This compound, with a Boc (tert-butoxycarbonyl) protecting group attached to the D-phenylalanine backbone, serves as a versatile building block in peptide and pharmaceutical synthesis.In chemical synthesis, Boc-D-Phe(3-F)-OH is commonly used for the solid-phase synthesis of peptides. The Boc protecting group plays a vital role in safeguarding the sensitive functional groups present in the amino acid during the various coupling and deprotection steps involved in peptide assembly. By selectively removing the Boc group under mild acidic conditions, the desired peptide sequence can be synthesized efficiently with high purity and yield.Furthermore, the incorporation of a fluorine atom at the ortho position of the phenylalanine side chain enhances the biological activity and metabolic stability of the peptides or pharmaceutical compounds synthesized using Boc-D-Phe(3-F)-OH. This fluorinated amino acid derivative has shown promise in the design and development of novel drug candidates, particularly in the fields of medicinal chemistry and drug discovery.Overall, the strategic application of Boc-D-Phe(3-F)-OH in chemical synthesis enables the efficient construction of complex peptides and pharmaceutical compounds with improved properties and potential therapeutic benefits.