Fmoc-Met(O)-OH, also known as N-(9-fluorenylmethoxycarbonyl)-methionine sulfoxide, is a commonly used building block in peptide synthesis and chemical research. This compound is a derivative of methionine, an essential amino acid, with an oxidation state of sulfone.In chemical synthesis, Fmoc-Met(O)-OH serves as a versatile tool for introducing a methionine residue with an oxidized sulfur atom into peptide chains. The Fmoc (9-fluorenylmethyloxycarbonyl) protecting group provides stability during peptide assembly while the sulfoxide group offers unique reactivity for further modifications. This allows researchers to precisely control the synthesis of peptides with specific functionalities or structural motifs.Additionally, the presence of the sulfoxide group in Fmoc-Met(O)-OH can play a critical role in modulating the biological activity and stability of peptides. The incorporation of a sulfoxide moiety in peptide sequences can lead to enhanced proteolytic resistance and altered physicochemical properties, making it a valuable tool for drug development and biochemical studies.Overall, Fmoc-Met(O)-OH is a key component in the toolbox of chemists and researchers working in the field of peptide chemistry, providing opportunities for tailored peptide design and functionalization in various applications.
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