
Catalog Number	AR01CC3P
Chemical Name	3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride,[2R-(2a,3a,4a,5b)]-
CAS Number	75172-81-5
Molecular Formula	C6H14ClNO4
Molecular Weight	199.6327
MDL Number	MFCD00269962
SMILES	OC[C@H]1NC[C@@H]([C@H]([C@H]1O)O)O.Cl

Migalastat hydrochloride, also known as Galafold, is a pharmacological chaperone used in the treatment of Fabry disease. It functions by binding to mutant forms of the alpha-galactosidase A enzyme, which are responsible for the defects seen in Fabry disease patients. Through this mechanism, migalastat hydrochloride helps stabilize the enzyme, allowing it to traffic to the lysosomes where it can function more effectively in breaking down globotriaosylceramide (GL-3) and related substrates. This targeted approach is considered a significant advancement in the management of Fabry disease, offering a more specific and personalized treatment option for patients with certain genetic mutations. In chemical synthesis, migalastat hydrochloride can serve as a model compound for designing and developing other pharmacological chaperones. Its structure and mode of action provide valuable insights into the interactions between small molecules and target proteins, aiding in the rational design of new drug candidates for various genetic disorders. By studying the effects of migalastat hydrochloride on enzyme stability and functionality, researchers can better understand the principles of chaperone therapy and apply this knowledge to the development of novel treatments for other inherited metabolic diseases.

1-Butanol, 4-amino-

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Cyclobutylboronic acid

849052-26-2

$6.00/100mg, $11.00/250mg, $26.00/1g, $105.00/5g, $191.00/10g, $389.00/25g, $1,283.00/100g,

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6-Bromo-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride

105655-01-4

$5.00/100mg, $9.00/250mg, $22.00/1g, $71.00/5g, $137.00/10g, $288.00/25g, $972.00/100g,

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1-((BENZYLOXY)CARBONYL)-3-AMINOPIPERIDINE-3-CARBOXYLIC ACID

1131595-03-3

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Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate

1408168-76-2

$11.00/250mg, $17.00/500mg, $30.00/1g, $136.00/5g, $260.00/10g, $520.00/25g, $900.00/50g,

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CHEMHERE CHEM147002

1417638-80-2

$14.00/100mg, $30.00/250mg, $87.00/1g, $260.00/5g, $433.00/10g, $866.00/25g,

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Packsize	Purity	Price	Availability
1mg	98%	$30.00	Global Stock	Buy Now	Add To Cart
5mg	98%	$90.00	Global Stock	Buy Now	Add To Cart
10mg	98%	$135.00	Global Stock	Buy Now	Add To Cart
25mg	98%	$270.00	Global Stock	Buy Now	Add To Cart
50mg	98%	$458.00	Global Stock	Buy Now	Add To Cart
100mg	98%	$825.00	Global Stock	Buy Now	Add To Cart

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride,[2R-(2a,3a,4a,5b)]-