Z-D-Asp(OtBu)-OH, also known as N-Benzyloxycarbonyl-L-aspartic acid β-tert-butyl ester, is a commonly used amino acid derivative in chemical synthesis. This compound plays a crucial role as a building block in the preparation of peptides and small molecule drugs.
Z-D-Asp(OtBu)-OH is primarily utilized in solid-phase peptide synthesis and solution-phase synthesis to create peptide sequences with specific functionalities and structural features. Its tert-butyl ester group provides protection to the aspartic acid residue during peptide elongation, allowing for controlled manipulations of peptide chains without undesired reactions. Furthermore, the benzyl carbamate moiety safeguards the amino group, enabling selective deprotection at a later stage of the synthesis process.
Overall, Z-D-Asp(OtBu)-OH facilitates the efficient assembly of peptides and peptide mimetics in chemical research and drug development applications.
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