
Catalog Number	AR00ICEK
Chemical Name	Fmoc-Cys(tBu)-OH
CAS Number	67436-13-9
Molecular Formula	C22H25NO4S
Molecular Weight	399.5032
MDL Number	MFCD00037130
SMILES	O=C(N[C@H](C(=O)O)CSC(C)(C)C)OCC1c2ccccc2-c2c1cccc2

Fmoc-Cys(tBu)-OH, a derivative of cysteine, is a crucial building block in peptide and protein synthesis due to its unique properties. This compound is widely employed as a protected form of cysteine, allowing for selective deprotection and subsequent coupling reactions in solid-phase peptide synthesis. The Fmoc (9-fluorenylmethyloxycarbonyl) group serves as a temporary protecting group, shielding the thiol functionality of cysteine to prevent unwanted side reactions during peptide assembly. The tert-butyl (tBu) protecting group on the sulfhydryl moiety further enhances the stability of Fmoc-Cys(tBu)-OH, making it a valuable tool in the construction of complex peptide sequences. This versatile reagent enables chemists to introduce cysteine residues into peptides with precise control over the reaction conditions, facilitating the synthesis of bioactive peptides, peptidomimetics, and modified proteins. With its strategic role in peptide chemistry, Fmoc-Cys(tBu)-OH continues to be an indispensable component in the toolbox of researchers and synthetic chemists striving to unlock the potential of peptide-based therapeutics and biomolecular engineering.

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