2-Thioxothiazolidin-4-one, also known as rhodanine, is a versatile compound widely utilized in chemical synthesis for various applications. In the field of medicinal chemistry, it serves as a valuable scaffold for the design and development of pharmaceutical agents. Rhodanine derivatives exhibit diverse biological activities, including antimicrobial, anticancer, antiviral, and anti-inflammatory properties, making them promising candidates for drug discovery.Additionally, 2-Thioxothiazolidin-4-one is frequently employed in organic synthesis as a key building block for the construction of heterocyclic compounds. Its unique structure allows for facile functionalization, enabling the formation of complex molecules with specific properties and functionalities. By serving as a precursor in the synthesis of heterocycles, rhodanine plays a crucial role in the development of novel materials and substances with potential applications in various industries.Moreover, the reactivity of 2-Thioxothiazolidin-4-one makes it a valuable tool in chemical transformations such as Michael additions, cyclization reactions, and condensation processes. Its ability to participate in diverse synthetic pathways provides chemists with a versatile platform for creating molecular architectures with tailored properties. Overall, the significance of 2-Thioxothiazolidin-4-one in chemical synthesis lies in its versatility, reactivity, and utility across a wide range of applications.